Free webinars of Associates of Cape Cod, Inc.:
- Mar, 2026 – Case study: Experience With Alternative LAL Methods at Bayer’s Bergkamen Site.
- Jun, 2022 – Comparison of traditional LAL to Recombinant Reagents – Veronika Wills
- Jun, 2021 – LAL Today/LAL Tomorrow – Veronika Wills
- Jun, 2021 – LAL Today/LAL Tomorrow – Brett Hoffmeister
- May, 2021 – Sustainability in Bacterial Endotoxin Testing – A Holistic Approach – Part II
- Mar, 2021 – Bacterial Endotoxin Testing And It’s Sustainable Alternative
- Dec, 2020 – Sustainability In Bacterial Endotoxin Testing; A Holistic Approach to Conservation and Recombinant Technology
- Sep, 2020 – Current Bacterial Endotoxins Test (BET) and its Intended Use
- Apr, 2020 – Recombinant chromogenic assay as an alternate method for the Bacterial Endotoxins Test (BET)
- Nov, 2019 – The status of recombinant reagents used for Bacterial Endotoxin Testing (BET)
Experience With Alternative LAL Methods at Bayer's Bergkamen Site
March 17, 2026
News in BET: Comparison of traditional LAL to Recombinant Reagents – Veronika Wills
June 7, 2022
LAL Today/LAL Tomorrow – Veronika Wills
June 23, 2021
LAL Today/LAL Tomorrow - Brett Hoffmeister
Jun, 2021
Sustainability In Bacterial Endotoxin Testing - A Holistic Approach - Part II
May, 2021
Bacterial Endotoxin Testing And It's Sustainable Alternative
March, 2021
Sustainability In Bacterial Endotoxin Testing; A Holistic Approach to Conservation and Recombinant Technology
December, 2020
Current Bacterial Endotoxins Test (BET) and its Intended Use
September, 2020
Overview:
The Bacterial Endotoxins Test is not a test for pyrogens (fever causing agents). It is not a test for the presence of Gram negative bacteria. Based on extensive comparisons of endotoxins activity in the BET and fever rabbits executed in the 1970s and 1980s, we may say that the BET is a test for levels of Gram negative bacterial endotoxins activity that may be predictive of a fever in mammals.
The various methodologies that are described in the harmonized in the harmonized chapter use the primary Reference Endotoxin Standard (RSE) or secondary Control Standard Endotoxin (CSE) to prepare assay standards, perform suitability testing as instructed in the chapter and inoculate positive product controls. These standards are relatively pure preparations of lipopolysaccharide. However, the utility of the compendial assay for non-compendial applications is limited. Our discussion will focus on the compendial uses of these BET assays.
Recombinant Chromogenic Assay as an Alternate Method for The Bacterial Endotoxins Test (BET)
April, 2020
The Status of Recombinant Reagents Used for Bacterial Endotoxin Testing (BET)
November, 2019
Overview:
There has been a lot of discussion associated with the potential for use of synthetic (non-animal based) reagents for bacterial endotoxin testing. This free webinar provides an overview of the current status of the recombinant reagents on the global market. It will also lay out the recent proposed changes to USP <85>.