Factor VIII deficiency
In cases of hemophilia, i.e. deficiency of FVIII or IX, the intrinsic tenase does not work normally impairing propagation of the clot.
Comparison of thrombodynamics results for a patient with severe hemophilia A and healthy donor is shown.
Clot formation is initiated normally, but resultant clot growth is slow. Numerical parameters are shown in the table. V is decreased while Tlag does not change.