Symbol
Name
MW (kDa)
Plasma concentration
Synthesis
Half-Life
in vivo
Contact phase
FXII
Hageman Factor
80
30 µg/ml
Liver
2-3 days
FXI
Plasma thromboplastin antecedent
160
Homodimer
3-7 µg/ml
Liver
2-3 days
HMWK / HK
High molecular weight kininogen
85
30-50 µg/ml
Liver
5-6 days
PK
Prekallikrein
120
60-80 µg/ml
Liver
1-2 days
Vitamin K dependent proteins
FII
Prothrombin
72
100 µg/ml
Liver
1-2 days
FVII
Proconvertin
50
0.3-0.5 µg/ml
Liver
4-6 hours
FX
Stuart-Prower-Factor
58
8-12 µg/ml
Liver
1-2 days
APC
Protein C
62
4-5 µg/ml
Liver
4-6 hours
PS
Protein S
69
10 µg/ml (free)
25 µg/ml (total)
Liver
1-2 days
PZ
Protein Z
62
2-4 µg/ml
Liver
2-3 days
Inhibitors
α2-MG
α2-Macroglobuline
725
2-5 mg/ml
Liver,
endothelial cells
2-3 days
HCoII
Heparin CO-II
66
90 µg/mL
Liver
2-3 days
PAI-3
Protein C inhibitor
57
5 µg/mL
Liver
1 day
TFPI
Tissue factor pathway inhibitor
33
8-15 ng/mL (free)
60-100 ng/mL (total)
Endothelial cells
–
(short)
ZPI
Protein Z inhibitor
72
3-7 µg/mL
Liver
2-3 days
Cofactors
FV
Proaccelerin
330
10 µg/mL
Liver, megacaryocytes
12 hours
TM
Thrombomodulin
60
Expressed on endothelial cells
Endothelial cells
–
Fibrinolysis
C1-INH
C1-inhibitor
106
180 µg/mL
Liver
1-2 days
Plg
Plasminogen
90
200 µg/mL
Liver
2-3 days
HRGP
Histidine-rich glycoprotein
67
100 µg/mL
Liver
3 days
α2-AP
Alpha 2-antiplasmin
70
70 µg/mL
Hepatocytes
60 hours
tPA
Tissue plasminogen activator
68
<10 ng/mL
Endothelial cells
5 min
PAI-2
Plasminogen-activator inhibitor-2
47
<10 ng/mL
Placenta, leukocytes, macrophages
120 min
Others
C4b-BP
C4b-binding protein
590
250 µg/mL
–
2-3 days
vWF
Von Willebrand factor
500-2000 (sub-units of 260)
8-12 µg/mL
Endothelial cells, liver, megacaryocytes
12 hours
TF
Tissue Factor
45
Extra vascular
Many non vascular cells, monocytes, endothelial cells
–
(short)
FI
Fibrinogen
340
2-4 mg/mL
Liver
2-3 days
β2GP1
anti-β2 glycoprotein 1
50
200 µg/mL
Liver
–
FXIII
Fibrin stabilizing factor / plasma transglutaminase
320 (A2B2 Complex)
10-15 µg/mL
Liver
3-4 days
