Proteins Involved in Haemostasis and Fibrinolysis

Symbol
Name
MW (kDa)
Plasma concentration
Synthesis
Half-Life
in vivo

Contact phase

FXII

Hageman Factor

80

30 µg/ml

Liver

2-3 days

FXI

Plasma thromboplastin antecedent

160
Homodimer

3-7 µg/ml

Liver

2-3 days

HMWK / HK

High molecular weight kininogen

85

30-50 µg/ml

Liver

5-6 days

PK

Prekallikrein

120

60-80 µg/ml

Liver

1-2 days

Vitamin K dependent proteins

FII

Prothrombin

72

100 µg/ml

Liver

1-2 days

FVII

Proconvertin

50

0.3-0.5 µg/ml

Liver

4-6 hours

Antihaemophilic factor B / Christmas factor

55

4-5 µg/ml

Liver

24 hours

FX

Stuart-Prower-Factor

58

8-12 µg/ml

Liver

1-2 days

APC

Protein C

62

4-5 µg/ml

Liver

4-6 hours

PS

Protein S

69

10 µg/ml (free)
25 µg/ml (total)

Liver

1-2 days

PZ

Protein Z

62

2-4 µg/ml

Liver

2-3 days

Inhibitors

ATIII

Antithrombin III

58

150 µg/ml

Liver

2-3 days

α2-MG

α2-Macroglobuline

725

2-5 mg/ml

Liver,
endothelial cells

2-3 days

HCoII

Heparin CO-II

66

90 µg/mL

Liver

2-3 days

PAI-3

Protein C inhibitor

57

5 µg/mL

Liver

1 day

TFPI

Tissue factor pathway inhibitor

33

8-15 ng/mL (free)
60-100 ng/mL (total)

Endothelial cells


(short)

ZPI

Protein Z inhibitor

72

3-7 µg/mL

Liver

2-3 days

Cofactors

FV

Proaccelerin

330

10 µg/mL

Liver, megacaryocytes

12 hours

Antihaemophilic globulin A

265

0.1 µg/mL

Liver

12 hours

TM

Thrombomodulin

60

Expressed on endothelial cells

Endothelial cells

Fibrinolysis

C1-INH

C1-inhibitor

106

180 µg/mL

Liver

1-2 days

Plg

Plasminogen

90

200 µg/mL

Liver

2-3 days

HRGP

Histidine-rich glycoprotein

67

100 µg/mL

Liver

3 days

α2-AP

Alpha 2-antiplasmin

70

70 µg/mL

Hepatocytes

60 hours

tPA

Tissue plasminogen activator

68

<10 ng/mL

Endothelial cells

5 min

uPA

Urokinase plasminogen activator

55

<5 ng/mL

Kidney

8 min

PAI-1

Plasminogen activator inhibitor-1

50

<30 ng/mL

Endothelial cells, liver, megacaryocytes

5 min

PAI-2

Plasminogen-activator inhibitor-2

47

<10 ng/mL

Placenta, leukocytes, macrophages

120 min

TAFI

Trombin activatable fibronolysis inhibitor

60

2.5 µg/mL

Liver

Others

C4b-BP

C4b-binding protein

590

250 µg/mL

2-3 days

vWF

Von Willebrand factor

500-2000 (sub-units of 260)

8-12 µg/mL

Endothelial cells, liver, megacaryocytes

12 hours

TF

Tissue Factor

45

Extra vascular

Many non vascular cells, monocytes, endothelial cells


(short)

FI

Fibrinogen

340

2-4 mg/mL

Liver

2-3 days

β2GP1

anti-β2 glycoprotein 1

50

200 µg/mL

Liver

FXIII

Fibrin stabilizing factor / plasma transglutaminase

320 (A2B2 Complex)

10-15 µg/mL

Liver

3-4 days